The leaves of Chinopodium album Linn. Family Chinopodiaceae have been used in Ayurvedic medicine since ancient times for the treatment of male sexual disorders. The present study is aimed to investigate the effect ethanolic extract of bathua on general mating behaviour, libido, and potency along with its likely adverse effects on sexually normal male Swiss Albino mice. The suspension of the extract was administered orally at the dose of 100, 250, and 500 mg / kg v/v, to different groups of male rats (n = 6) once a day for seven days. The female albino mice involved in mating were made receptive by hormonal treatment. The general mounting frequency, libido and potency were determined and compared with the standard reference drug sildenafil citrate. The probable gastric ulceration and adverse effects of the extract were also evaluated. The hormonal parameter like testosterone was evaluated. Oral administration of the extract significantly increased the Mounting Frequency and increase in sex hormone testosterone was estimated. The most appreciable effect of the extract was observed at the dose of 500 mg/kg. The test drug was also found to be devoid of any conspicuous gastric ulceration and adverse effects. The results indicated that the ethanolic extract of Chinopodium album Linn. Family Chinopodiaceae produced a significant and sustained increase in the sexual activity of normal male mice, without any adverse effects. Thus, the resultant aphrodisiac effectivity of the extract lends support to the claims for its traditional usage in sexual disorders.
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